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C5051
Sigma
C-Peptide human
≥95% (HPLC)
| Synonym: | Insulin C chain, Arg-Arg-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-Lys-Arg |
| CAS Number: | 11097-48-6 |
| Linear Formula: | C153H259N49O52 |
| Molecular Weight: | 3616.99 |
| MDL number: | MFCD00076294 |
Description
| Biochem/physiol Actions | In proinsulin the insulin A and B chains are linked by C peptide. During the biosynthesis of insulin, the C peptide promotes proper protein folding and disulfide bond placement after which it is cleaved. The cleaved peptide may inhibit insulin aggregation and is stored and released from the β cells with insulin in a one-to-one molar ratio. C peptide is a marker for β cell function in vivo; levels are enhanced in insulin resistance or insuloma and reduced in insulin insufficiency (type I diabetes). C peptide may alleviate the vascular damage and neuropathy associated with insulin depletion. |
Properties
| assay | ≥95% (HPLC) |
| storage temp. | −20°C |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Steiner, D.F., The proinsulin C-peptide − a multirole model. Exp. Diabesity Res. 5, 7-14, (2004) |
| Shafqat, J., et al., Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects. Cell. Mol. Life Sci. 63, 1805-1811, (2006) | |
| Marques, R.G., et al., C-peptide: much more than a byproduct of insulin biosynthesis. Pancreas 29, 231-238, (2004) | |
| Palmer, J.P., et al., C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve β-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 53, 250-264, (2004) | |
| Joshua, I.G., et al., Mechanisms of endothelial dysfunction with development of type 1 diabetes mellitus: role of insulin and C-peptide. J. Cell. Biochem. 96, 1149-1156, (2005) | |
| Forst, T., and Kunt, T., Effects of C-peptide on microvascular blood flow and blood hemorheology. Exp. Diabesity Res. 5, 51-64, (2004) | |
| Sima, A.A., et al., Type 1 diabetic neuropathy and C-peptide. Exp. Diabesity Res. 5, 65-77, (2004) |
